Heterozygous Loss of Yap1 in Mice Causes Progressive Cataracts.

ABSTRACT:

Purpose

Yap1 encodes an evolutionarily conserved transcriptional coactivator and functions as a down-stream effector of the Hippo signaling pathway that controls tissue size and cell growth. Yap1 contributes to lens epithelial development. However, the effect of Yap1 haplodeficiency on the lens epithelium and its role in the development of cataracts has not been reported. The aim of the current study is to investigate Yap1 function and its regulatory mechanisms in lens epithelial cells (LECs).

Methods

Lens phenotypes were investigated in Yap1 heterozygous mutant mice by visual observation and histological and biochemical methods. Primary LEC cultures were used to study regulatory molecular mechanism.

Results

The heterozygous inactivation of Yap1 in mice caused catarac

SUBMITTER: Lu Q 

PROVIDER: S-EPMC7585397 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature