Wireless sensor enables longitudinal monitoring of regenerative niche mechanics during rehabilitation that enhance bone repair.

ABSTRACT: Mechanical loads exerted on the skeleton during activities such as walking are important regulators of bone repair, but dynamic biomechanical signals are difficult to measure inside the body. The inability to measure the mechanical environment in injured tissues is a significant barrier to developing integrative regenerative and rehabilitative strategies that can accelerate recovery from fracture, segmental bone loss, and spinal fusion. Here we engineered an implantable strain sensor platform and longitudinally measured strain across a bone defect in real-time throughout rehabilitation. The results showed that load-sharing permitted by a load-sharing fixator initially delivered a two-fold increase in deformation magnitude, subsequently increased mineralized bridging by nearly three-fold, a

SUBMITTER: Klosterhoff BS 

PROVIDER: S-EPMC7585453 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature