Association Analysis Between Common Variants of the TRPM1 Gene and Three Mental Disorders in the Han Chinese Population.

ABSTRACT: Objective: Our study was designed to determine if the TRPM1 gene is associated with any of three mental disorders. The project included a cross disorder meta-analysis and association analysis including 141701 cases and 175248 controls. Materials and Methods: We genotyped eight tag single nucleotide polymorphisms (SNPs) in 1248 unrelated schizophrenia (SCZ) patients, 1056 major depressive disorder patients, 1344 bipolar disorder patients, and 1248 normal controls. We then performed a meta-analysis of 10 GWASs to identify common genetic factors among these three mental disorders. Finally, we performed a meta-analysis of six GWASs to explore the role of rs10162727 in SCZ. Result: Although two haplotypes of the TRPM1 gene, rs1035706-rs101

SUBMITTER: Ma C 

PROVIDER: S-EPMC7585623 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature