Chorioallantoic Membrane Tumor Model for Evaluating Oncolytic Viruses.

ABSTRACT: Oncolytic viruses are promising anticancer agents; however, regarding their clinical efficacy, there is still significant scope for improvement. Preclinical in vivo evaluation of oncolytic viruses is mainly based on syngeneic or xenograft tumor models in mice, which is labor-intensive and time-consuming. Currently, a large proportion of developmental work in the research field of oncolytic viruses is directed toward overcoming cellular and noncellular barriers to achieve improved virus delivery to primary tumors and metastases. To evaluate the large number of genetically or chemically modified viruses regarding tumor delivery and biodistribution patterns, it would be valuable to have an in vivo model available that would allow easy screening experiments, that is of higher com

SUBMITTER: Krutzke L 

PROVIDER: S-EPMC7585625 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature