Systemic Effects Induced by Hyperoxia in a Preclinical Model of Intra-abdominal Sepsis.

ABSTRACT: Supplemental oxygen is a supportive treatment in patients with sepsis to balance tissue oxygen delivery and demand in the tissues. However, hyperoxia may induce some pathological effects. We sought to assess organ damage associated with hyperoxia and its correlation with the production of reactive oxygen species (ROS) in a preclinical model of intra-abdominal sepsis. For this purpose, sepsis was induced in male, Sprague-Dawley rats by cecal ligation and puncture (CLP). We randomly assigned experimental animals to three groups: control (healthy animals), septic (CLP), and sham-septic (surgical intervention without CLP). At 18 h after CLP, septic (n = 39), sham-septic (n = 16), and healthy (n = 24) animals were placed within a sealed Plexiglas cage and randomly distribut

SUBMITTER: Garcia-Laorden MI 

PROVIDER: S-EPMC7585649 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature