Higher white matter hyperintensity lesion load is associated with reduced long-range functional connectivity.

ABSTRACT: Cerebral small vessel disease is a common disease in the older population and is recognized as a major risk factor for cognitive decline and stroke. Small vessel disease is considered a global brain disease impacting the integrity of neuronal networks resulting in disturbances of structural and functional connectivity. A core feature of cerebral small vessel disease commonly present on neuroimaging is white matter hyperintensities. We studied high-resolution resting-state EEG, leveraging source reconstruction methods, in 35 participants with varying degree of white matter hyperintensities without clinically evident cognitive impairment in an observational study. In patients with increasing white matter lesion load, global theta power was increased independently of age. Whole-brain function

SUBMITTER: Quandt F 

PROVIDER: S-EPMC7585696 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature