IGFBP6 Is Downregulated in Unstable Carotid Atherosclerotic Plaques According to an Integrated Bioinformatics Analysis and Experimental Verification.

ABSTRACT:

Aims

To investigate the differentially expressed genes (DEGs) and molecular interaction in unstable atherosclerotic carotid plaques.

Methods

Gene expression datasets GSE41571, GSE118481, and E-MTAB-2055 were analyzed. Co-regulated DEGs in at least two datasets were analyzed with the enrichment of Gene Ontology Biological Process (GO-BP), Kyoto Encyclopedia of Genes and Genomes (KEGG), protein-protein interaction (PPI) networks, interrelationships between miRNAs/transcriptional factors, and their target genes and drug-gene interactions. The expression of notable DEGs in human carotid artery plaques and plasma was further identified.

Results

The GO-BP enrichment analysis revealed that genes associated with inflammatory response, and extracellular matrix organization wer

SUBMITTER: Liu Y 

PROVIDER: S-EPMC7585910 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature