Modelling of pathogen-host systems using deeper ORF annotations and transcriptomics to inform proteomics analyses.

ABSTRACT: The Zika virus is a flavivirus that can cause fulminant outbreaks and lead to Guillain-Barré syndrome, microcephaly and fetal demise. Like other flaviviruses, the Zika virus is transmitted by mosquitoes and provokes neurological disorders. Despite its risk to public health, no antiviral nor vaccine are currently available. In the recent years, several studies have set to identify human host proteins interacting with Zika viral proteins to better understand its pathogenicity. Yet these studies used standard human protein sequence databases. Such databases rely on genome annotations, which enforce a minimal open reading frame (ORF) length criterion. An ever-increasing number of studies have demonstrated the shortcomings of such annotation, which overlooks thousands of functional ORFs. Here w

SUBMITTER: Leblanc S 

PROVIDER: S-EPMC7585943 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature