Transcriptome network data in larval zebrafish (Danio rerio) following exposure to the phenylpyrazole fipronil.

ABSTRACT: Fipronil is a phenylpyrazole pesticide that is used in both residential and agricultural applications. Fipronil is detected in run-off and water systems that are near areas in which the pesticide has been applied. The pesticide acts to antagonize gamma aminobutyric acid receptors, leading to over-excitation in the central nervous system. Fipronil has relatively high toxicity to fish, but the mechanisms underlying the toxicity are not well understood in embryonic stages. Zebrafish embryos were exposed to a single concentration of fipronil for 48 h at ∼3-4 h-post-fertilization. Following a 7-day depuration phase, transcriptome and behavioral analyses were conducted. Transcriptomics identified neural processes as those differentially expressed with different doses of fipronil (0.2 µg, 200 µg

SUBMITTER: Eadie A 

PROVIDER: S-EPMC7586098 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature