IFN-γ Mediates the Development of Systemic Lupus Erythematosus.

ABSTRACT:

Objective

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect all organs in the body. It is characterized by overexpression of antibodies against autoantigen. Although previous bioinformatics analyses have identified several genetic factors underlying SLE, they did not discriminate between naive and individuals exposed to anti-SLE drugs. Here, we evaluated specific genes and pathways in active and recently diagnosed SLE population.

Methods

GSE46907 matrix downloaded from Gene Expression Omnibus (GEO) was analyzed using R, Metascape, STRING, and Cytoscape to identify differentially expressed genes (DEGs), enrichment pathways, protein-protein interaction (PPI), and hub genes between naive SLE individuals and healthy controls.

Results

A tot

SUBMITTER: Liu W 

PROVIDER: S-EPMC7586164 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature