Investigating the Relationship Between Age and Kidney Failure in Adults With Category 4 Chronic Kidney Disease.

ABSTRACT:

Background

In people with severe chronic kidney disease (CKD), there is an inverse relationship between age and kidney failure. If this relationship is the same at any age (linear), one effect (hazard ratio) will be sufficient for accurate risk prediction; if it is nonlinear, the effect will vary with age.

Objective

To investigate the relationship between age and kidney failure in adults with category G4 chronic kidney disease (G4 CKD).

Methods

We performed a population-based study using linked administrative databases in Alberta, Canada, to study adults with G4 CKD (estimated glomerular filtration rate [eGFR] = 15-30 mL/min/1.73 m²) and without previously documented eGFR <15 mL/min/1.73 m² or renal replacement. We used cause-specific Cox regress

SUBMITTER: Al-Wahsh H 

PROVIDER: S-EPMC7586273 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature