Skilled reaching tasks for head-fixed mice using a robotic manipulandum.

ABSTRACT: Skilled forelimb behaviors are among the most important for studying motor learning in multiple species including humans. This protocol describes learned forelimb tasks for mice using a two-axis robotic manipulandum. Our device provides a highly compact adaptation of actuated planar two-axis arms that is simple and inexpensive to construct. This paradigm has been dominant for decades in primate motor neuroscience. Our device can generate arbitrary virtual movement tracks, arbitrary time-varying forces or arbitrary position- or velocity-dependent force patterns. We describe several example tasks permitted by our device, including linear movements, movement sequences and aiming movements. We provide the mechanical drawings and source code needed to assemble and control the device, and detail

SUBMITTER: Wagner MJ 

PROVIDER: S-EPMC7586302 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature