Maternal Obesity Affects the Glucose-Insulin Axis During the First Trimester of Human Pregnancy.

ABSTRACT: Background and objective: The maternal glucose-insulin axis is central for metabolic adaptations required for a healthy pregnancy. Metabolic changes in obese mothers in early pregnancy have been scantly described. Here we characterized the glucose-insulin axis in the first trimester of human pregnancy and assessed the effect of maternal obesity and fat mass. Methods: In this cross-sectional study, maternal blood samples (N = 323) were collected during voluntary pregnancy termination (gestational age 4⁺⁰-11⁺⁶ weeks) after overnight fasting. Smokers (N = 198) were identified by self-report and serum cotinine levels (ELISA). Maternal BMI (kg/m²) and serum leptin (ELISA) were used as proxy measures of obesity and maternal fat mass, r

SUBMITTER: Bandres-Meriz J 

PROVIDER: S-EPMC7586307 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature