Literature based discovery of alternative TCM medicine for adverse reactions to depression drugs.

ABSTRACT:

Background

In recent years, Traditional Chinese Medicine (TCM) and alternative medicine have been widely used along with western drugs as a complementary form of treatment. In this study, we first use the scientific literature to identify western drugs with obvious side effects. Then, we find TCM alternatives for these western drugs to ameliorate their side effects.

Results

We used depression as a case study. To evaluate our method, we showed the relation between herb-ingredients-target-disease for representative alternative herbs of western drugs. Further, a protein-protein interaction network of western drugs and alternative herbs was produced, and we performed enrichment analysis of the targets of the active ingredients of the herbs and examined the enrichment of Gene Ont

SUBMITTER: Xie Q 

PROVIDER: S-EPMC7586667 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature