RNA editing in cancer impacts mRNA abundance in immune response pathways.

ABSTRACT:

Background

RNA editing generates modifications to the RNA sequences, thereby increasing protein diversity and shaping various layers of gene regulation. Recent studies have revealed global shifts in editing levels across many cancer types, as well as a few specific mechanisms implicating individual sites in tumorigenesis or metastasis. However, most tumor-associated sites, predominantly in noncoding regions, have unknown functional relevance.

Results

Here, we carry out integrative analysis of RNA editing profiles between epithelial and mesenchymal tumors, since epithelial-mesenchymal transition is a key paradigm for metastasis. We identify distinct editing patterns between epithelial and mesenchymal tumors in seven cancer types using TCGA data, an observation further support

SUBMITTER: Chan TW 

PROVIDER: S-EPMC7586670 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature