Ketogenic diet aggravates cardiac remodeling in adult spontaneously hypertensive rats.

ABSTRACT:

Background

Ketogenic diet (KD) has been proposed to be an effective lifestyle intervention in metabolic syndrome. However, the effects of KD on cardiac remodeling have not been investigated. Our aim was to investigate the effects and the underling mechanisms of KD on cardiac remodeling in spontaneously hypertensive rats (SHRs).

Methods

10-week-old spontaneously hypertensive rats were subjected to normal diet or ketogenic diet for 4 weeks. Then, their blood pressure and cardiac remodeling were assessed. Cardiac fibroblasts were isolated from 1- to 3-day-old neonatal pups. The cells were then cultured with ketone body with or without TGF-β to investigate the mechanism in vitro.

Results

4 weeks of KD feeding aggravated interstitial fibrosis and cardiac remodeling

SUBMITTER: You Y 

PROVIDER: S-EPMC7586698 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature