A moisturizer formulated with glycerol and propylene glycol accelerates the recovery of skin barrier function after experimental disruption in dogs.

ABSTRACT:

Background

Moisturizers are foundational therapies for human atopic dermatitis. In veterinary medicine, the use of moisturizers has been recommended by an expert committee to alleviate skin dryness that would occur, for example, in canine atopic dermatitis (cAD). However, little is known regarding the effects of moisturizers on the skin barrier.

Hypothesis/objectives

To investigate the effects of a moisturizer on skin barrier recovery in a canine model of chronic mechanical barrier disruption.

Animals

Six healthy beagle dogs maintained in a laboratory setting.

Methods and materials

A model of chronic skin barrier disruption was simulated by tape stripping on both sides of the thorax. The moisturizer then was applied twice daily for one week to one side of the t

SUBMITTER: Panzuti P 

PROVIDER: S-EPMC7586792 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature