Dataset Information

Click-Chemistry (CuAAC) Trimerization of an α_v β₆ Integrin Targeting Ga-68-Peptide: Enhanced Contrast for in-Vivo PET Imaging of Human Lung Adenocarcinoma Xenografts.

ABSTRACT: α_v β₆ Integrin is an epithelial transmembrane protein that recognizes latency-associated peptide (LAP) and primarily activates transforming growth factor beta (TGF-β). It is overexpressed in carcinomas (most notably, pancreatic) and other conditions associated with α_v β₆ integrin-dependent TGF-β dysregulation, such as fibrosis. We have designed a trimeric Ga-68-labeled TRAP conjugate of the α_v β₆ -specific cyclic pentapeptide SDM17 (cyclo[RGD-Chg-E]-CONH₂ ) to enhance α_v β₆ integrin affinity as well as target-specific in-vivo uptake. Ga-68-TRAP(SDM17)₃ showed a 28-fold higher α_v β₆ affinity than the corresponding monomer Ga-68-NOTA-SDM17 (IC₅₀ of 0.

SUBMITTER: Quigley NG

PROVIDER: S-EPMC7586803 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Dataset Information

Click-Chemistry (CuAAC) Trimerization of an α_v β₆ Integrin Targeting Ga-68-Peptide: Enhanced Contrast for in-Vivo PET Imaging of Human Lung Adenocarcinoma Xenografts.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Click-Chemistry (CuAAC) Trimerization of an αv β6 Integrin Targeting Ga-68-Peptide: Enhanced Contrast for in-Vivo PET Imaging of Human Lung Adenocarcinoma Xenografts.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Click-Chemistry (CuAAC) Trimerization of an α_v β₆ Integrin Targeting Ga-68-Peptide: Enhanced Contrast for in-Vivo PET Imaging of Human Lung Adenocarcinoma Xenografts.