Ontology highlight
ABSTRACT:
SUBMITTER: Smith NA
PROVIDER: S-EPMC7586913 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Smith Nicholas A NA Clarke Oliver B OB Lee Mihwa M Hodder Anthony N AN Smith Brian J BJ
Protein science : a publication of the Protein Society 20201005 11
PfSERA5, a significantly abundant protein present within the parasitophorous vacuole (PV) and essential for normal growth during the blood-stage life cycle of the malaria parasite Plasmodium falciparum, displays structural similarity to many other cysteine proteases. However, PfSERA5 does not exhibit any detectable protease activity and therefore the role of the PfSERA5 papain-like domain (PfSERA5E), thought to remain bound to its cognate prodomain, remains unknown. In this study, we present a r ...[more]