Genome-wide DNA methylation patterns associated with sleep and mental health in children: a population-based study.

ABSTRACT:

Background

DNA methylation (DNAm) has been implicated in the biology of sleep. Yet, how DNAm patterns across the genome relate to different sleep outcomes, and whether these associations overlap with mental health is currently unknown. Here, we investigated associations of DNAm with sleep and mental health in a pediatric population.

Methods

This cross-sectional study included 465 10-year-old children (51.3% female) from the Generation R Study. Genome-wide DNAm levels were measured using the Illumina 450K array (peripheral blood). Sleep problems were assessed from self-report and mental health outcomes from maternal questionnaires. Wrist actigraphy was used in 188 11-year-old children to calculate sleep duration and midpoint sleep. Weighted gene co-expression network analysis

SUBMITTER: Koopman-Verhoeff ME 

PROVIDER: S-EPMC7586967 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature