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Synthesis of Tetrahydroquinolines via Borrowing Hydrogen Methodology Using a Manganese PN³ Pincer Catalyst.

ABSTRACT: A straightforward and selective synthesis of 1,2,3,4-tetrahydroquinolines starting from 2-aminobenzyl alcohols and simple secondary alcohols is reported. This one-pot cascade reaction is based on the borrowing hydrogen methodology promoted by a manganese(I) PN³ pincer complex. The reaction selectively leads to 1,2,3,4-tetrahydroquinolines thanks to a targeted choice of base. This strategy provides an atom-efficient pathway with water as the only byproduct. In addition, no further reducing agents are required.

SUBMITTER: Hofmann N

PROVIDER: S-EPMC7587143 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Synthesis of Tetrahydroquinolines via Borrowing Hydrogen Methodology Using a Manganese PN³ Pincer Catalyst.

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Synthesis of Tetrahydroquinolines via Borrowing Hydrogen Methodology Using a Manganese PN3 Pincer Catalyst.

OmicsDI is part of the ELIXIR infrastructure

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Synthesis of Tetrahydroquinolines via Borrowing Hydrogen Methodology Using a Manganese PN³ Pincer Catalyst.