ORCA study: real-world versus reading centre assessment of disease activity of neovascular age-related macular degeneration (nAMD).

ABSTRACT:

Background/aims

The prospective, non-interventional ORCA module of the OCEAN study (Observation of Treatment Patterns with Lucentis in Approved Indications) evaluated the qualiy of spectral domain-optical coherence tomography (SD-OCT) image interpretation and treatment decisions by clinicians in Germany and the impact on visual outcomes over 24 months in patients with neovascular age-related macular degeneration (nAMD).

Methods

2286 SD-OCT scans of 205 eyes were independently evaluated by clinicians and reading centres (RCs) regarding signs of choroidal neovascularisation (CNV) activity, including presence of intraretinal fluid, subretinal fluid, and/or increase in pigment epithelial detachments. Agreement between clinicians and RCs was calculated. Treatment decisions by cli

SUBMITTER: Liakopoulos S 

PROVIDER: S-EPMC7587226 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature