Blockade of IL-33 signalling attenuates osteoarthritis.

ABSTRACT:

Objectives

Osteoarthritis (OA) is the most common form of arthritis characterised by cartilage degradation, synovitis and pain. Disease modifying treatments for OA are not available. The critical unmet need is to find therapeutic targets to reduce both disease progression and pain. The cytokine IL-33 and its receptor ST2 have been shown to play a role in immune and inflammatory diseases, but their role in osteoarthritis is unknown.

Methods

Non-OA and OA human chondrocytes samples were examined for IL-33 and ST2 expression. Novel inducible cartilage specific knockout mice (IL-33^{Acan CreERT2}) and inducible fibroblast-like synoviocyte knockout mice (IL-33^{Col1a2 CreERT2}) were generated and subjected to an experimental OA model. In addition, wild-type mice w

SUBMITTER: He Z 

PROVIDER: S-EPMC7587452 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature