Microbe-Driven Genotoxicity in Gastrointestinal Carcinogenesis.

ABSTRACT: The intestinal epithelium serves as a barrier to discriminate the outside from the inside and is in constant exchange with the luminal contents, including nutrients and the microbiota. Pathogens have evolved mechanisms to overcome the multiple ways of defense in the mucosa, while several members of the microbiota can exhibit pathogenic features once the healthy barrier integrity of the epithelium is disrupted. This not only leads to symptoms accompanying the acute infection but may also contribute to long-term injuries such as genomic instability, which is linked to mutations and cancer. While for Helicobacter pylori a link between infection and cancer is well established, many other bacteria and their virulence factors have only recently been linked to gastrointestinal malignancies

SUBMITTER: Hartl K 

PROVIDER: S-EPMC7587957 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature