Aberrant computational mechanisms of social learning and decision-making in schizophrenia and borderline personality disorder.

ABSTRACT: Psychiatric disorders are ubiquitously characterized by debilitating social impairments. These difficulties are thought to emerge from aberrant social inference. In order to elucidate the underlying computational mechanisms, patients diagnosed with major depressive disorder (N = 29), schizophrenia (N = 31), and borderline personality disorder (N = 31) as well as healthy controls (N = 34) performed a probabilistic reward learning task in which participants could learn from social and non-social information. Patients with schizophrenia and borderline personality disorder performed more poorly on the task than healthy controls and patients with major depressive disorder. Broken down by domain, borderline personality disorder patients performed better in the social compared to the non-social d

SUBMITTER: Henco L 

PROVIDER: S-EPMC7588082 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature