Influence of probiotic supplementation on the developing microbiota in human preterm neonates.

ABSTRACT:

Background

Oral administration of probiotic bacteria to preterm neonates has been recommended to prevent the development of necrotizing enterocolitis (NEC). The influence of probiotics on the endogenous microbiome, however, has remained incompletely understood.

Study design & methods

Here, we performed an observational study including 80 preterm neonates born at a gestational age <32-weeks to characterize the persistence of probiotic bacteria after no treatment or oral administration of two different probiotic formula and their influence on the microbial ecosystem during and after the intervention and their association with the development of NEC. Weekly fecal samples were profiled by 16S rRNA sequencing and monitored for the presence of the probiotic bacteria by quantitativ

SUBMITTER: van Best N 

PROVIDER: S-EPMC7588225 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature