Chrysin mitigated obesity by regulating energy intake and expenditure in rats.

ABSTRACT:

Background and aim

Chrysin is a flavonoid found in plant extracts from Passiflora species, honey and propolis. It has demonstrated anti-adipogenic activity in vitro but there are no studies substantiating the anti-obesity activity of chrysin in vivo.

Experimental procedure

The pancreatic lipase (PL) inhibitory potential of chrysin was determined by preliminary in silico screening and further confirmed by in vitro PL inhibitory assay and oral fat tolerance test (OFTT). The effect of chrysin on acute feed intake and sucrose preference test was determined in normal rats. Obesity was induced by feeding of high fructose diet (HFD) to the rats. The rats were divided into six groups: normal control, HFD control, orlistat and three doses of chrysin

SUBMITTER: Pai SA 

PROVIDER: S-EPMC7588347 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature