Cerebellar Volumes Associate with Behavioral Phenotypes in Prader-Willi Syndrome.

ABSTRACT: The objective of this study was to investigate lobule-specific cerebellar structural alterations relevant to clinical behavioral characteristics of Prader-Willi syndrome (PWS). We performed a case-control study of 21 Japanese individuals with PWS (age; median 21.0, range 13-50 years, 14 males, 7 females) and 40 age- and sex-matched healthy controls with typical development. Participants underwent 3-Tesla magnetic resonance imaging. Three-dimensional T₁-weighted images were assessed for cerebellar lobular volume and adjusted for total intracerebellar volume (TIV) using a spatially unbiased atlas template to give a relative volume ratio. A region of interest analysis included the deep cerebellar nuclei. A correlation analysis was performed between the volumetric data and the clini

SUBMITTER: Yamada K 

PROVIDER: S-EPMC7588377 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature