Markers of neutrophil activation and extracellular traps formation are predictive of appendicitis in mice and humans: a pilot study.

ABSTRACT: Appendicitis is one of the most frequent emergencies in pediatric surgery, yet current biomarkers for diagnosis are unspecific and have low predictive values. As neutrophils and extracellular traps (ETs) are an essential component of the immune defense against bacterial infections, and appendicitis is considered an inflammation reaction of the appendix, we hypothesized that neutrophil activation and NET formation play an essential role in appendicitis development and maintenance. Therefore, this pilot study aimed to establish a murine model of appendicitis and to evaluate ETs markers to diagnose appendicitis in mice and humans. The study used 20 (12 appendicitis- and 8 controls) 6-week old mice which underwent advanced appendicitis induction using a modified caecal ligation puncture proced

SUBMITTER: Boettcher M 

PROVIDER: S-EPMC7588418 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature