Predictive assembling model reveals the self-adaptive elastic properties of lamellipodial actin networks for cell migration.

ABSTRACT: Branched actin network supports cell migration through extracellular microenvironments. However, it is unknown how intracellular proteins adapt the elastic properties of the network to the highly varying extracellular resistance. Here we develop a three-dimensional assembling model to simulate the realistic self-assembling process of the network by encompassing intracellular proteins and their dynamic interactions. Combining this multiscale model with finite element method, we reveal that the network can not only sense the variation of extracellular resistance but also self-adapt its elastic properties through remodeling with intracellular proteins. Such resistance-adaptive elastic behaviours are versatile and essential in supporting cell migration through varying extracellular microenviro

SUBMITTER: Chen X 

PROVIDER: S-EPMC7588425 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature