Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC7588425 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Chen Xindong X Zhu Hanxing H Feng XiQiao X Li Xiaona X Lu Yongtao Y Wang Zuobin Z Rezgui Yacine Y
Communications biology 20201026 1
Branched actin network supports cell migration through extracellular microenvironments. However, it is unknown how intracellular proteins adapt the elastic properties of the network to the highly varying extracellular resistance. Here we develop a three-dimensional assembling model to simulate the realistic self-assembling process of the network by encompassing intracellular proteins and their dynamic interactions. Combining this multiscale model with finite element method, we reveal that the ne ...[more]