Cerebrospinal fluid neopterin as a biomarker of neuroinflammatory diseases.

ABSTRACT: The elevation of neopterin in cerebrospinal fluid (CSF) has been reported in several neuroinflammatory disorders. However, it is not expected that neopterin alone can discriminate among different neuroinflammatory etiologies. We conducted an observational retrospective and case-control study to analyze the CSF biomarkers neopterin, total proteins, and leukocytes in a large cohort of pediatric patients with neuroinflammatory disorders. CSF samples from 277 subjects were included and classified into four groups: Viral meningoencephalitis, bacterial meningitis, acquired immune-mediated disorders, and patients with no-immune diseases (control group). CSF neopterin was analyzed with high-performance liquid chromatography. Microbiological diagnosis included bacterial CSF cultures and several spe

SUBMITTER: Molero-Luis M 

PROVIDER: S-EPMC7588460 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature