Effects of gintonin-enriched fraction on hippocampal gene expressions.

ABSTRACT:

Background

Recently, gintonin and gintonin-enriched fraction (GEF) have been isolated from ginseng, a herbal medicine. Gintonin induces [Ca²⁺]_i transition in cultured hippocampal neurons and stimulates acetylcholine release through LPA receptor activation. Oral administration of GEF is linked to hippocampus-dependent cognitive enhancement and other neuroprotective effects; however, effects of its long-term administration on hippocampal gene expression remains unknown. Here, we used next-generation sequence (NGS) analysis to examine changes in hippocampal gene expressions after long-term oral administration of GEF.

Methods

C57BL/6 mice were divided into three groups: control group, GEF50 (GEF 50 mg/kg, p.o.), and GEF100 (GEF 100 mg/kg, p.o.

SUBMITTER: Lee R 

PROVIDER: S-EPMC7588706 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature