Melatonin attenuates AFB1-induced cardiotoxicity via the NLRP3 signalling pathway.

ABSTRACT:

Objective

This study was conducted to investigate the protective effect of melatonin against aflatoxin B1 (AFB1) cardiotoxicity by evaluating NOD-like receptor family pyrin domain containing protein 3 (NLRP3) signalling.

Methods

Four groups of five rats each were assessed: control group (vehicle only), two AFB1 (0.15 and 0.3 mg/kg)-treated groups, and a combined AFB1 (0.3 mg/kg) plus melatonin (5 mg/kg)-treated group. After 6 weeks of once-daily intragastric treatment, cardiac pathologic changes were observed under optical microscopy, and oxidative/antioxidative parameters were measured in myocardial homogenate. Cardiac tissue expression of NLRP3 and other important inflammasome components was also analysed.

Results

Compared with controls, increasing concentrat

SUBMITTER: Yan H 

PROVIDER: S-EPMC7588772 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature