Administration of all-trans retinoic acid after experimental traumatic brain injury is brain protective.

ABSTRACT:

Background and purpose

All-trans retinoic acid (ATRA) is a vitamin A metabolite, important in the developing and mature brain. Pre-injury ATRA administration ameliorates ischaemic brain insults in rodents. This study examined the effects of post-traumatic ATRA treatment in experimental traumatic brain injury (TBI).

Experimental approach

Male adult mice were subjected to the controlled cortical impact model of TBI or sham procedure and killed at 7 or 30 days post-injury (dpi). ATRA (10 mg kg-1, i.p.) was given immediately after the injury and 1, 2 and 3 dpi. Neurological function and sensorimotor coordination were evaluated. Brains were processed for (immuno-) histological, mRNA and protein analyses (qPCR and western blot).

Key results

ATRA treatment reduced brain lesi

SUBMITTER: Hummel R 

PROVIDER: S-EPMC7588818 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature