Streptococcus pneumoniae aminopeptidase N regulates dendritic cells that attenuates type-2 airway inflammation in murine allergic asthma.

ABSTRACT:

Background and purpose

Epidemiological and experimental studies suggest that microbial exposure in early childhood is linked with reduced risk to suffer asthma. Thus microbial components with immunoregulatory capabilities might serve as a preventive strategy for allergic asthma. Recently, it was identified that Streptococcus pneumoniae aminopeptidase N (PepN) could suppress T cell effector function. We sought to investigate the effect of PepN on murine allergic asthma and elucidate the underlying mechanism.

Experimental approach

The effects of intranasal administration of PepN during or before sensitization were examined in ovalbumin (OVA)-induced murine allergic asthma. The roles of CD11b⁺ dendritic cells in PepN treated OVA-induced allergic asthma were evaluated

SUBMITTER: Wu G 

PROVIDER: S-EPMC7588821 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature