Antibacterial Activity of Chromomycins from a Marine-Derived Streptomyces microflavus.

ABSTRACT: A marine-derived actinomycete (Streptomyces sp. MBTI36) exhibiting antibacterial activities was investigated in the present study. The strain was identified using genetic techniques. The 16S rDNA sequence of the isolate indicated that it was most closely related to Streptomyces microflavus. Furthermore, a new chromomycin A₉ (1), along with chromomycin Ap (2), chromomycin A₂ (3), and chromomycin A₃ (4), were isolated from the ethyl acetate extract. Their structures were determined using extensive spectroscopic methods including 1D and 2D NMR, and HRMS, as well as comparisons with previously reported data. Compounds 1-4 showed potent antibacterial activities against Gram-positive bacteria including methi

SUBMITTER: Cho E 

PROVIDER: S-EPMC7588889 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature