MiR-302 Regulates Glycolysis to Control Cell-Cycle during Neural Tube Closure.

ABSTRACT: Neural tube closure is a critical early step in central nervous system development that requires precise control of metabolism to ensure proper cellular proliferation and differentiation. Dysregulation of glucose metabolism during pregnancy has been associated with neural tube closure defects (NTDs) in humans suggesting that the developing neuroepithelium is particularly sensitive to metabolic changes. However, it remains unclear how metabolic pathways are regulated during neurulation. Here, we used single-cell mRNA-sequencing to analyze expression of genes involved in metabolism of carbon, fats, vitamins, and antioxidants during neurulation in mice and identify a coupling of glycolysis and cellular proliferation to ensure proper neural tube closure. Using loss of miR-302 as a genet

SUBMITTER: Keuls RA 

PROVIDER: S-EPMC7589003 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature