Maternal sildenafil impairs the cardiovascular adaptations to chronic hypoxaemia in fetal sheep.

ABSTRACT:

Key points

Fetal growth restriction induces a haemodynamic response that aims to maintain blood flow to vital organs such as the brain, in the face of chronic hypoxaemia Maternal sildenafil treatment impairs the hypoxaemia-driven haemodynamic response and potentially compromises fetal development.

Abstract

Inadequate substrate delivery to a fetus results in hypoxaemia and fetal growth restriction (FGR). In response, fetal cardiovascular adaptations redirect cardiac output to essential organs to maintain oxygen delivery and sustain development. However, FGR infants remain at risk for cardiovascular and neurological sequelae. Sildenafil citrate (SC) has been examined as a clinical therapy for FGR, but also crosses the placenta and may exert direct effects on the fetus. We inve

SUBMITTER: Inocencio IM 

PROVIDER: S-EPMC7589206 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature