Healthy Donors Harbor Memory T Cell Responses to RAS Neo-Antigens.

ABSTRACT: The RAS mutations are the most frequently occurring somatic mutations in humans, and several studies have established that T cells from patients with RAS-mutant cancer recognize and kill RAS-mutant cells. Enhancing the T cell response via therapeutic cancer vaccination against mutant RAS results in a clinical benefit to patients; thus, T cells specific to RAS mutations are effective at battling cancer. As the theory of cancer immuno-editing indicates that healthy donors may clear malignantly transformed cells via immune-mediated killing, and since T cells have been shown to recognize RAS-mutant cancer cells, we investigated whether healthy donors harbor T-cell responses specific to mutant RAS. We identified strong and frequent responses against several epitopes derived from the RAS codon 1

SUBMITTER: Holmstrom MO 

PROVIDER: S-EPMC7589254 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature