Paracellular bicarbonate flux across human cystic fibrosis airway epithelia tempers changes in airway surface liquid pH.

ABSTRACT:

Key points

Cl^- and HCO₃^- had similar paracellular permeabilities in human airway epithelia. P_Cl /P_Na of airway epithelia was unaltered by pH 7.4 vs. pH 6.0 solutions. Under basal conditions, calculated paracellular HCO₃^- flux was secretory. Cytokines that increased airway surface liquid pH decreased or reversed paracellular HCO₃^- flux. HCO₃^- flux through the paracellular pathway may counterbalance effects of cellular H⁺ and HCO₃^- secretion.

Abstract

Airway epithelia control the pH of airway surface liquid (ASL), thereby optimizing respiratory defences. Active H⁺ and HCO₃^- secretion by airway

SUBMITTER: Thornell IM 

PROVIDER: S-EPMC7589346 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature