Risk of major depressive disorder in Japanese cancer patients: A matched cohort study using employer-based health insurance claims data.

ABSTRACT:

Objective

Patients with cancer are at high risk of depression. However, the risk of major depressive disorder (MDD) after cancer diagnosis has not been studied in a population setting in Japan. This cohort study used a Japanese medical claims database to examine time to MDD in cancer patients and the risk of MDD (hazard ratio; HR) compared with matched cancer-free controls.

Methods

Primary endpoint was time to MDD (starting 6 months before cancer diagnosis) in adult (18-74 years) cancer patients; secondary endpoint was time to MDD (6 months before to 12 months after cancer diagnosis) in a matched cohort of cancer patients and cancer-free controls. Multivariate analyses were performed to determine HRs for all cancers and for each cancer site.

Results

Of 35 008 cancer p

SUBMITTER: Akechi T 

PROVIDER: S-EPMC7589376 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature