Hydrogenase Mimics in M₁₂ L₂₄ Nanospheres to Control Overpotential and Activity in Proton-Reduction Catalysis.

ABSTRACT: Hydrogenase enzymes are excellent proton reduction catalysts and therefore provide clear blueprints for the development of nature-inspired synthetic analogues. Mimicking their catalytic center is straightforward but mimicking the protein matrix around the active site and all its functions remains challenging. Synthetic models lack this precisely controlled second coordination sphere that provides substrate preorganization and catalyst stability and, as a result, their performances are far from those of the natural enzyme. In this contribution, we report a strategy to easily introduce a specific yet customizable second coordination sphere around synthetic hydrogenase models by encapsulation inside M₁₂ L₂₄ cages and, at the same time, create a proton-rich nano-environme

SUBMITTER: Zaffaroni R 

PROVIDER: S-EPMC7589440 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature