SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes.

ABSTRACT: Interventional studies on genetic modulators of longevity have significantly changed gerontology. While available lifespan data are continually accumulating, further understanding of the aging process is still limited by the poor understanding of epistasis and of the non-linear interactions between multiple longevity-associated genes. Unfortunately, based on observations so far, there is no simple method to predict the cumulative impact of genes on lifespan. As a step towards applying predictive methods, but also to provide information for a guided design of epistasis lifespan experiments, we developed SynergyAge - a database containing genetic and lifespan data for animal models obtained through multiple longevity-modulating interventions. The studies included in SynergyAge focus on the l

SUBMITTER: Bunu G 

PROVIDER: S-EPMC7589469 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature