Osteogenic potential of human adipose derived stem cells (hASCs) seeded on titanium trabecular spinal cages.

ABSTRACT: Spine degenerative conditions are becoming increasingly prevalent, affecting about 5.7% of the population in Europe, resulting in a significant reduction of life's quality. Up to now, many materials have been used in manufacturing cage implants, used as graft substitutes, to achieve immediate and long-term spinal fixation. Particularly, titanium and its alloys are emerging as valuable candidates to develop new types of cages. The aim of this in vitro study was to evaluate the adhesion, proliferation and osteogenic differentiation of adipose derived mesenchymal stem cells (ASCs) seeded on trabecular titanium cages. ASCs adhered, proliferated and produced an abundant extracellular matrix during the 3 weeks of culture. In the presence of osteogenic medium, ASCs differentiated into osteoblast-

SUBMITTER: Caliogna L 

PROVIDER: S-EPMC7589498 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature