A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening.

ABSTRACT: Acceleration and unification of drug discovery is important to reduce the effort and cost of new drug development. Diverse chemical and biological conditions, specialized infrastructure and incompatibility between existing analytical methods with high-throughput, nanoliter scale chemistry make the whole drug discovery process lengthy and expensive. Here, we demonstrate a chemBIOS platform combining on-chip chemical synthesis, characterization and biological screening. We developed a dendrimer-based surface patterning that enables the generation of high-density nanodroplet arrays for both organic and aqueous liquids. Each droplet (among > 50,000 droplets per plate) functions as an individual, spatially separated nanovessel, that can be used for solution-based synthesis or analytical assays.

SUBMITTER: Benz M 

PROVIDER: S-EPMC7589500 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature