Advanced Methods for Studying Structure and Interactions of Macrolide Antibiotics.

ABSTRACT: Macrolide antibiotics are macrocyclic compounds that are clinically used and prescribed for the treatment of upper and lower respiratory tract infections. They inhibit the synthesis of bacterial proteins by reversible binding to the 23S rRNA at or near the peptidyl transferase center. However, their excellent antibacterial profile was largely compromised by the emergence of bacterial resistance. Today, fighting resistance to antibiotics is one of the greatest challenges in medicinal chemistry. Considering various physicochemical properties of macrolides, understanding their structure and interactions with macromolecular targets is crucial for the design of new antibiotics efficient against resistant pathogens. The solid-state structures of some macrolide-ribosome complexes have recently be

SUBMITTER: Jednacak T 

PROVIDER: S-EPMC7589898 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature