Non-Muscle-Invasive Bladder Carcinoma with Respect to Basal Versus Luminal Keratin Expression.

ABSTRACT: Non-muscle-invasive bladder cancer (NMIBC) consists of transcriptional subtypes that are distinguishable from those of muscle-invasive cancer. We aimed to identify genetic signatures of NMIBC related to basal (K5/6) and luminal (K20) keratin expression. Based on immunohistochemical staining, papillary high-grade NMIBC was classified into K5/6-only (K5/6^High-K20^Low), K20-only (K5/6^Low-K20^High), double-high (K5/6^High-K20^High), and double-low (K5/6^Low-K20^Low) groups (n = 4 per group). Differentially expressed genes identified between each group using RNA sequencing were subjected to functional enrichment analyses. A public dataset was used for validation. Machine learning algorithms were implemented to pre

SUBMITTER: Jung M 

PROVIDER: S-EPMC7589917 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature