Tiny Actors in the Big Cellular World: Extracellular Vesicles Playing Critical Roles in Cancer.

ABSTRACT: Communications among cells can be achieved either via direct interactions or via secretion of soluble factors. The emergence of extracellular vesicles (EVs) as entities that play key roles in cell-to-cell communication offer opportunities in exploring their features for use in therapeutics; i.e., management and treatment of various pathologies, such as those used for cancer. The potential use of EVs as therapeutic agents is attributed not only for their cell membrane-bound components, but also for their cargos, mostly bioactive molecules, wherein the former regulate interactions with a recipient cell while the latter trigger cellular functions/molecular mechanisms of a recipient cell. In this article, we highlight the involvement of EVs in hallmarks of a cancer cell, particularly focusing

SUBMITTER: Jurj A 

PROVIDER: S-EPMC7589964 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature