Validation of a prostate cancer polygenic risk score.

ABSTRACT:

Background

Genome-wide association studies have identified over 100 single-nucleotide polymorphisms (SNPs) associated with prostate cancer (PrCa), and polygenic risk scores (PRS) based on their combined genotypes have been developed for risk stratification. We aimed to assess the contribution of PRS to PrCa risk in a large multisite study.

Methods

The sample included 1972 PrCa cases and 1919 unaffected controls. Next-generation sequencing was used to assess pathogenic variants in 14 PrCa-susceptibility genes and 72 validated PrCa-associated SNPs. We constructed a population-standardized PRS and tested its association with PrCa using logistic regression adjusted for age and family history of PrCa.

Results

The mean age of PrCa cases at diagnosis and age of controls at t

SUBMITTER: Black MH 

PROVIDER: S-EPMC7590110 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature