The one-stage assay or chromogenic assay to monitor baseline factor VIII levels and desmopressin effect in non-severe haemophilia A: Superiority or non-inferiority?

ABSTRACT:

Introduction

Diagnosis, treatment monitoring and assessment of desmopressin effect in haemophilia A patients are performed by measurement of factor VIII activity (FVIII). The two assays commonly applied are the one-stage assay and the chromogenic assay. Especially in non-severe haemophilia A, discrepancies between these assays are common. It is still unestablished which assay corresponds best with bleeding phenotype and desmopressin effect.

Aim

To correlate FVIII levels measured by the one-stage assay and by the chromogenic assay with bleeding phenotype and, additionally, to compare FVIII assay discrepancies before and after desmopressin administration.

Method

Factor VIII was measured in 130 non-severe haemophilia A patients during routine visits to the outpatient cli

SUBMITTER: Schutte LM 

PROVIDER: S-EPMC7590113 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature